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phenobarbital will lessen the extent or outcome of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Sturdy or reasonable CYP3A4 inducers may well increase price of diazepam elimination; for that reason, efficacy of diazepam may be decreased.Practice Forming. Phenobarbital may be pattern forming.